34 MENOPAUSE SYMPTOMS |
HEALTH CENTER |
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PMS heralds mood deterioration during HRT |
Menopausal and postmenopausal women receiving hormone replacement therapy (HRT) are more likely to experience mood swings. A study published in The Journal of Clinical Endocrinology & Metabolism found that during certain cycles of the treatment women experienced changes in mood, including irritability, aggression, depression and hostility, which are comparable to premenstrual syndrome (PMS) symptoms.
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Although estrogen has been found to have a positive cognitive and physical effect in menopausal women, the study found that when higher levels of estrogen are combined with progestin, mood often deteriorates.
To explore this issue, a team of researchers carried out a study on 38 perimenopausal women from December 2000 to November 2001. The subjects noted their symptoms daily during sequential hormone replacement therapy.
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In the progestin cycle of HRT, women reported notable changes in mood, including irritability and depression, especially if the progestin was combined with higher levels of estrogen. Although it was previously thought that progestin is the main cause of negative mood swings experienced in HRT, this study found that when combined with progestin, estrogen is a factor, as well. |
Furthermore, women with a history of premenstrual symptoms will most likely suffer from more severe mood swings during HRT, says a study published in Climateric. The researchers followed 106 women during sequential HRT, evaluating their emotional and physical symptoms in response to the treatment. The study concluded that women who had a history of PMS suffered increased depression, tension and irritability in response to the progestin and estrogen in HRT as compared to women who had not suffered from PMS. |
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When considering HRT, patients who have a history of PMS should discuss the possible implications for their emotional health with their doctors.
By Natural-Progesterone-Estrogen-Supplements.com |
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